Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac Ischemia-Reperfusion.

ABSTRACT:

Background

Despite advances in treatment, myocardial infarction (MI) is a leading cause of heart failure and death worldwide, with both ischemia and reperfusion (I/R) causing cardiac injury. A previous study using a mouse model of nonreperfused MI showed activation of brown adipose tissue (BAT). Recent studies showed that molecules secreted by BAT target the heart. We investigated whether BAT attenuates cardiac injury in I/R and sought to identify potential cardioprotective proteins secreted by BAT.

Methods

Myocardial I/R surgery with or without BAT transplantation was performed in wild-type (WT) mice and in mice with impaired BAT function (uncoupling protein 1 [Ucp1]-deficient mice). To identify potential cardioprotective factors produced by BAT, RNA-seq (RNA sequenc

SUBMITTER: Marti-Pamies I 

PROVIDER: S-EPMC10528340 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature