B₁ inhomogeneity-corrected T₁ mapping and quantitative magnetization transfer imaging via simultaneously estimating Bloch-Siegert shift and magnetization transfer effects.

ABSTRACT:

Purpose

To introduce a method of inducing Bloch-Siegert shift and magnetization Transfer Simultaneously (BTS) and demonstrate its utilization for measuring binary spin-bath model parameters free pool spin-lattice relaxation ( T1F$$ {T}_1^{\mathrm{F}} $$ ), macromolecular fraction ( f$$ f $$ ), magnetization exchange rate ( kF$$ {k}_{\mathrm{F}} $$ ) and local transmit field ( B1+$$ {B}_1^{+} $$ ).

Theory and methods

Bloch-Siegert shift and magnetization transfer is simultaneously induced through the application of off-resonance irradiation in between excitation and acquisition of an RF-spoiled gradient-echo scheme. Applying the binary spin-bath model, an analytical signal equation is derived and verified through Bloch simulations. Monte Carlo simulations were performed to an

SUBMITTER: Jang A 

PROVIDER: S-EPMC10528411 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature