Investigations of a combination of atopic status and age of asthma onset identify asthma subphenotypes.

ABSTRACT:

Objective

Subphenotypes of asthma may be determined by age onset and atopic status. We sought to characterize early or late onset atopic asthma with fungal or non-fungal sensitization (AAFS or AANFS) and non-atopic asthma (NAA) in children and adults in the Severe Asthma Research Program (SARP). SARP is an ongoing project involving well-phenotyped patients with mild to severe asthma.

Methods

Phenotypic comparisons were performed using Kruskal-Wallis or chi-square test. Genetic association analyses were performed using logistic or linear regression.

Results

Airway hyper-responsiveness, total serum IgE levels, and T2 biomarkers showed an increasing trend from NAA to AANFS and then to AAFS. Children and adults with early onset asthma had greater % of AAFS than adults wit

SUBMITTER: Li H 

PROVIDER: S-EPMC10528448 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature