Prefrontal cortex melanocortin 4 receptors (MC4R) mediate food intake behavior in male mice.

ABSTRACT:

Background

Melanocortin 4 receptor (MC4R) activity in the hypothalamus is crucial for regulation of metabolism and food intake. The peptide ligands for the MC4R are associated with feeding, energy expenditure, and also with complex behaviors that orchestrate energy intake and expenditure, but the downstream neuroanatomical and neurochemical targets associated with these behaviors are elusive. In addition to strong expression in the hypothalamus, the MC4R is highly expressed in the medial prefrontal cortex, a region involved in executive function and decision-making.

Methods

Using viral techniques in genetically modified male mice combined with molecular techniques, we identify and define the effects on feeding behavior of a novel population of MC4R expressing neurons in the

SUBMITTER: Ross RA 

PROVIDER: S-EPMC10528493 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature