Pituitary gigantism: a case series from Hospital de San Jose (Bogota, Colombia).

ABSTRACT:

Introduction

Gigantism is a rare pediatric disease characterized by increased production of growth hormone (GH) before epiphyseal closure, that manifests clinically as tall stature, musculoskeletal abnormalities, and multiple comorbidities.

Materials and methods

Case series of 6 male patients with gigantism evaluated at the Endocrinology Service of Hospital de San José (Bogotá, Colombia) between 2010 and 2016.

Results

All patients had macroadenomas and their mean final height was 2.01 m. The mean age at diagnosis was 16 years, and the most common symptoms were headache (66%) and hyperhidrosis (66%). All patients had acral changes, and one had visual impairment secondary to compression of the optic chiasm. All patients underwent surgery, and 5 (83%) required additional

SUBMITTER: Garcia WR 

PROVIDER: S-EPMC10528647 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature