Polymorphisms of the renin-angiotensin system are not associated with overweight and obesity in a general adult population.

ABSTRACT:

Objective

The increased prevalence of obesity and associated comorbidities, such as cardiovascular and metabolic diseases, has gained attention worldwide, and the renin-angiotensin system (RAS) has been pointed out as a possible link. Thus, the present study aimed to verify the possible association between angiotensinogen (AGT) or angiotensin-converting enzyme (ACE) polymorphisms with overweight and obesity in adults.

Subjects and methods

The present investigation was a population-based cross-sectional study including 1,567 individuals from an urban area in Brazil. Anthropometric, clinical and biochemical parameters were evaluated, and all individuals were genotyped for the ACE I/D and AGT M/T polymorphisms.

Results

The prevalence of overweight was higher among men, w

SUBMITTER: Lelis DF 

PROVIDER: S-EPMC10528654 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature