Pro-myelinating clemastine administration improves recording performance of chronically implanted microelectrodes and nearby neuronal health.

ABSTRACT: Intracortical microelectrodes have become a useful tool in neuroprosthetic applications in the clinic and to understand neurological disorders in basic neurosciences. Many of these brain-machine interface technology applications require successful long-term implantation with high stability and sensitivity. However, the intrinsic tissue reaction caused by implantation remains a major failure mechanism causing loss of recorded signal quality over time. Oligodendrocytes remain an underappreciated intervention target to improve chronic recording performance. These cells can accelerate action potential propagation and provides direct metabolic support for neuronal health and functionality. However, implantation injury causes oligodendrocyte degeneration and leads to progressive demyelination in

SUBMITTER: Chen K 

PROVIDER: S-EPMC10528716 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature