Epigenome-wide association study using peripheral blood leukocytes identifies genomic regions associated with periodontal disease and edentulism in the Atherosclerosis Risk in Communities study.

ABSTRACT:

Aim

To investigate individual susceptibility to periodontitis by conducting an epigenome-wide association study using peripheral blood.

Materials and methods

We included 1077 African American and 457 European American participants of the Atherosclerosis Risk in Communities (ARIC) study who had completed a dental examination or reported being edentulous at Visit 4 and had available data on DNA methylation from Visit 2 or 3. DNA methylation levels were compared by periodontal disease severity and edentulism through discovery analyses and subsequent testing of individual CpGs.

Results

Our discovery analysis replicated findings from a previous study reporting a region in gene ZFP57 (6p22.1) that was significantly hypomethylated in severe periodontal disease compared with

SUBMITTER: Zhao N 

PROVIDER: S-EPMC10528731 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature