Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women.

ABSTRACT:

Background

Premature menopause is a risk factor for accelerated cardiovascular aging, but underlying mechanisms remain incompletely understood. This study investigated the role of leukocyte telomere length (LTL), a marker of cellular aging and genomic instability, in the association of premature menopause with cardiovascular disease.

Methods

Participants from the UK Biobank and Women's Health Initiative with complete reproductive history and LTL measurements were included. Primary analyses tested the association between age at menopause and LTL using multivariable-adjusted linear regression. Secondary analyses stratified women by history of gynecologic surgery. Mendelian randomization was used to infer causal relationships between LTL and age at natural menopause. Multivaria

SUBMITTER: Schuermans A 

PROVIDER: S-EPMC10528840 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature