Toward the use of MRI measurements of bound and pore water in fracture risk assessment.

ABSTRACT: The current clinical assessment of fracture risk lacks information about the inherent quality of a person's bone tissue. Working toward an imaging-based approach to quantify both a bone tissue quality marker (tissue hydration as water bound to the matrix) and a bone microstructure marker (porosity as water in pores), we hypothesized that the concentrations of bound water (C_bw) are lower and concentrations of pore water (C_pw) are higher in patients with osteoporosis (OP) than in age- and sex-matched adults without the disease. Using recent developments in ultrashort echo time (UTE) magnetic resonance imaging (MRI), maps of C_bw and C_pw were acquired from the uninjured distal third radius (Study 1) of 20 patients who experienced a fragility fracture

SUBMITTER: Nyman JS 

PROVIDER: S-EPMC10528882 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature