DESIGNER fraction concept unmasks minor bioactive constituents in red clover (Trifolium pratense L.).

ABSTRACT: In botanical extracts, highly abundant constituents can mask or dilute the effects of other, and often, more relevant biologically active compounds. To facilitate the rational chemical and biological assessment of these natural products with wide usage in human health, we introduced the DESIGNER approach of Depleting and Enriching Selective Ingredients to Generate Normalized Extract Resources. The present study applied this concept to clinical Red Clover Extract (RCE) and combined phytochemical and biological methodology to help rationalize the utility of RCE supplements for symptom management in postmenopausal women. Previous work has demonstrated that RCE reduces estrogen detoxification pathways in breast cancer cells (MCF-7) and, thus, may serve to negatively affect estrogen metabolism-

SUBMITTER: Hitzman R 

PROVIDER: S-EPMC10528883 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature