Cardiometabolic Effects of DOCA-Salt in Mice Depend on Ambient Temperature.

ABSTRACT:

Background

Mice prefer warmer environments than humans. For this reason, behavioral and physiological thermoregulatory responses are engaged by mice in response to a standard room temperature of 22 to 24 °C. Autonomic mechanisms mediating thermoregulatory responses overlap with mechanisms activated in hypertension, and, therefore, we hypothesized that housing at thermoneutral temperatures (TNs; 30 °C) would modify the cardiometabolic effects of deoxycorticosterone acetate (DOCA)-salt in mice.

Methods

The effects of DOCA-salt treatment upon ingestive behaviors, energy expenditure, blood pressure, heart rate (HR), and core temperature were assessed in C57BL/6J mice housed at room temperature or TN.

Results

Housing at TN reduced food intake, energy expenditure, blood pre

SUBMITTER: Grobe CC 

PROVIDER: S-EPMC10528934 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature