Deconvolution of immune cell composition and biological age of hepatocellular carcinoma using DNA methylation.

ABSTRACT: Hepatocellular carcinoma (HCC) has been an approved indication for the administration of immunotherapy since 2017, but biomarkers that predict therapeutic response have remained limited. Understanding and characterizing the tumor immune microenvironment enables better classification of these tumors and may reveal biomarkers that predict immunotherapeutic efficacy. In this paper, we applied a cell-type deconvolution algorithm using DNA methylation array data to investigate the composition of the tumor microenvironment in HCC. Using publicly available and in-house datasets with a total cohort size of 57 patients, each with tumor and matched normal tissue samples, we identified key differences in immune cell composition. We found that NK cell abundance was significantly decreased in HCC tumor

SUBMITTER: Jain SS 

PROVIDER: S-EPMC10529003 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature