Urinary Amino-PAHs in relation to diesel engine emissions and urinary mutagenicity.

ABSTRACT: Diesel exhaust has long been of health concern due to established toxicity including carcinogenicity in humans. However, the precise components of diesel engine emissions that drive carcinogenesis are still unclear. Limited work has suggested that nitrated polycyclic aromatic hydrocarbons (NPAHs) such as 1-nitropyrene and 2-nitrofluorene may be more abundant in diesel exhaust. The present study aimed to examine whether urinary amino metabolites of these NPAHs were associated with high levels of diesel engine emissions and urinary mutagenicity in a group of highly exposed workers including both smokers and nonsmokers. Spot urine samples were collected immediately following a standard work shift from each of the 54 diesel engine testers and 55 non-tester controls for the analysis of five ami

SUBMITTER: Zhang JJ 

PROVIDER: S-EPMC10529049 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature