Left Ventricular Dysfunction Associated With Brain Death: Results From the Donor Heart Study.

ABSTRACT:

Background

Left ventricular dysfunction in potential donors meeting brain death criteria often results in nonuse of donor hearts for transplantation, yet little is known about its incidence or pathophysiology. Resolving these unknowns was a primary aim of the DHS (Donor Heart Study), a multisite prospective cohort study.

Methods

The DHS enrolled potential donors by neurologic determination of death (n=4333) at 8 organ procurement organizations across the United States between February 2015 and May 2020. Data included medications administered, serial diagnostic tests, and transthoracic echocardiograms (TTEs) performed: (1) within 48 hours after brain death was formally diagnosed; and (2) 24±6 hours later if left ventricular (LV) dysfunction was initially present. LV dysfuncti

SUBMITTER: Khush KK 

PROVIDER: S-EPMC10529108 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature