Spatial learning impairments and discoordination of entorhinal-hippocampal circuit coding following prolonged febrile seizures.

ABSTRACT: How the development and function of neural circuits governing learning and memory are affected by insults in early life remains poorly understood. The goal of this study was to identify putative changes in cortico-hippocampal signaling mechanisms that could lead to learning and memory deficits in a clinically relevant developmental pathophysiological rodent model, Febrile status epilepticus (FSE). FSE in both pediatric cases and the experimental animal model, is associated with enduring physiological alterations of the hippocampal circuit and cognitive impairment. Here, we deconstruct hippocampal circuit throughput by inducing slow theta oscillations in rats under urethane anesthesia and isolating the dendritic compartments of CA1 and dentate gyrus subfields, their reception of medial and

SUBMITTER: Kloc ML 

PROVIDER: S-EPMC10529121 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature