Comparative analysis between zebrafish and an automated live-cell assay to classify developmental neurotoxicant chemicals.

ABSTRACT: Modern toxicology's throughput has dramatically increased due to alternative models, laboratory automation, and machine learning. This has enabled comparative studies across species and assays to prioritize chemical hazard potential and to understand how different model systems might complement one another. However, such comparative studies of high-throughput data are still in their infancy, with more groundwork needed to firmly establish the approach. Therefore, this study aimed to compare the bioactivity of the NIEHS Division of Translational Toxicology's (DTT) 87-compound developmental neurotoxicant (DNT) library in zebrafish and an in vitro high-throughput cell culture system. The early life-stage zebrafish provided a whole animal approach to developmental toxicity assessment. Chemical

SUBMITTER: St Mary L 

PROVIDER: S-EPMC10529185 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature