A network pharmacological approach to investigate the pharmacological effects of CZ2HF decoction on Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common type of dementia, which brings tremendous burden to the sufferers and society. However, ideal tactics are unavailable for AD. Our previous study has shown that CZ2HF, a Chinese herb preparation, mitigates cognitive impairment in AD rats; whereas, its detailed mechanism has not been elucidated.

Methods

Public databases were applied to collect and identify the chemical ingredients of eight herbs in CZ2HF. Criteria of absorption, distribution, metabolism, and excretion was used to screen oral bio-availability and drug-likeness. STITCH database and Therapeutic Target Database were applied to decipher the relationship between compounds and genes related to AD. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology term ana

SUBMITTER: Wei Y 

PROVIDER: S-EPMC10529192 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature