An evolutionarily nascent architecture underlying the formation and emergence of biomolecular condensates.

ABSTRACT: Biomolecular condensates are implicated in core cellular processes such as gene regulation and ribosome biogenesis. Although the architecture of biomolecular condensates is thought to rely on collective interactions between many components, it is unclear how the collective interactions required for their formation emerge during evolution. Here, we show that the structure and evolution of a recently emerged biomolecular condensate, the nucleolar fibrillar center (FC), is explained by a single self-assembling scaffold, TCOF1. TCOF1 is necessary to form the FC, and it structurally defines the FC through self-assembly mediated by homotypic interactions of serine/glutamate-rich low-complexity regions (LCRs). Finally, introduction of TCOF1 into a species lacking the FC is sufficient to form an F

SUBMITTER: Jaberi-Lashkari N 

PROVIDER: S-EPMC10529244 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature