4D printing of biocompatible, hierarchically porous shape memory polymeric structures.

ABSTRACT: Conventional implants tend to have significant limitations, as they are one-size-fits-all, require monitoring, and have the potential for immune rejection. However, 4D Printing presents a method to manufacture highly personalized, shape-changing, minimally invasive biomedical implants. Shape memory polymers (SMPs) with a glass transition temperature (T_g) between room and body temperature (20-38 °C) are particularly desirable for this purpose, as they can be deformed to a temporary shape before implantation, then undergo a shape change within the body. Commonly used SMPs possess either an undesirable T_g or lack the biocompatibility or mechanical properties necessary to match soft biological tissues. In this work, Poly(glycerol dodecanoate) acrylate (PGDA) with engineer

SUBMITTER: Bond G 

PROVIDER: S-EPMC10529366 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature