Input density tunes Kenyon cell sensory responses in the Drosophila mushroom body.

ABSTRACT: The ability to discriminate sensory stimuli with overlapping features is thought to arise in brain structures called expansion layers, where neurons carrying information about sensory features make combinatorial connections onto a much larger set of cells. For 50 years, expansion coding has been a prime topic of theoretical neuroscience, which seeks to explain how quantitative parameters of the expansion circuit influence sensory sensitivity, discrimination, and generalization. Here, we investigate the developmental events that produce the quantitative parameters of the arthropod expansion layer, called the mushroom body. Using Drosophila melanogaster as a model, we employ genetic and chemical tools to engineer changes to circuit development. These allow us to produce living animals with h

SUBMITTER: Ahmed M 

PROVIDER: S-EPMC10529417 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature