Histone demethylase KDM5D upregulation drives sex differences in colon cancer.

ABSTRACT: Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the molecular and genetic bases of such sex differences are ill-defined and presumptively ascribed to X-chromosome genes and sex hormones¹. Such sex differences are particularly prominent in colorectal cancer (CRC) in which men experience higher metastases and mortality. A murine CRC model, engineered with an inducible transgene encoding oncogenic mutant KRAS^G12D and conditional null alleles of Apc and Trp53 tumour suppressors (designated iKAP)², revealed higher metastases and worse outcomes specifically in males with oncogenic mutant KRAS (KRAS*) CRC. Integrated cross-species molecular and transcriptomic analyses identified Y-chromosome gene histone demethylase KDM5D as a transcri

SUBMITTER: Li J 

PROVIDER: S-EPMC10529424 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature