Cardiac resynchronization therapy in patients with a prior history of atrial fibrillation: Insights from four major clinical trials.

ABSTRACT:

Aims

To investigate the association of cardiac resynchronization therapy (CRT) on outcomes among participants with and without a history of atrial fibrillation (AF).

Methods

Individual-patient-data from four randomized trials investigating CRT-Defibrillators (COMPANION, MADIT-CRT, REVERSE) or CRT-Pacemakers (COMPANION, MIRACLE) were analyzed. Outcomes were time to a composite of heart failure hospitalization or all-cause mortality or to all-cause mortality alone. The association of CRT on outcomes for patients with and without a history of AF was assessed using a Bayesian-Weibull survival regression model adjusting for baseline characteristics.

Results

Of 3964 patients included, 586 (14.8%) had a history of AF; 2245 (66%) were randomized to CRT. Overall, CRT reduced t

SUBMITTER: Dalgaard F 

PROVIDER: S-EPMC10529427 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature