Differential Volume Increase of Endolymphatic Compartments in Meniere's Disease Is Inversely Associated With Membrane Thickness.

ABSTRACT:

Objectives

Our aim in this study was to characterize the morphology of the endolymphatic compartment on histopathology in individuals with Ménière's disease (MD) and to determine why hydrops of the saccule is more pronounced than that of other compartments of the inner ear in MD.

Methods

Temporal bones from 9 patients with idiopathic MD and from 10 individuals without MD/endolymphatic hydrops were examined. The inner ear fluid compartments in normal ears, and ears with MD were three-dimensionally reconstructed and their volume was calculated. The thickness of the membranes of the labyrinth was measured, and both ruptures of the membranes and patency of the utriculoendolymphatic (UEV; Bast's) valve were assessed.

Results

In ears with MD, the saccule and the cochlear du

SUBMITTER: Buki B 

PROVIDER: S-EPMC10529428 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature