A systematic comparison of VBM pipelines and their application to age prediction.

ABSTRACT: Voxel-based morphometry (VBM) analysis is commonly used for localized quantification of gray matter volume (GMV). Several alternatives exist to implement a VBM pipeline. However, how these alternatives compare and their utility in applications, such as the estimation of aging effects, remain largely unclear. This leaves researchers wondering which VBM pipeline they should use for their project. In this study, we took a user-centric perspective and systematically compared five VBM pipelines, together with registration to either a general or a study-specific template, utilizing three large datasets (n>500 each). Considering the known effect of aging on GMV, we first compared the pipelines in their ability of individual-level age prediction and found markedly varied results. To examine whethe

SUBMITTER: Antonopoulos G 

PROVIDER: S-EPMC10529438 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature