Indoor (residential) and ambient particulate matter associations with urinary oxidative stress biomarkers in a COPD cohort.

ABSTRACT:

Objectives

Oxidative stress contributes to chronic obstructive pulmonary disease (COPD) pathophysiology. Associations between indoor (residential) exposure to particulate matter ≤2.5 μm in diameter (PM_2.5) and one of its components, black carbon (BC), and oxidative stress are ill-defined.

Methods

Between 2012 and 2017, 140 patients with COPD completed in-home air sampling over one week intervals, followed by collection of urine samples to measure oxidative stress biomarkers, malondialdehyde (MDA), a marker of lipid peroxidation, and 8-hydroxy-2' -deoxyguanosine (8-OHdG), a marker of oxidative DNA damage. Ambient (central site) BC and PM_2.5 were measured, and the ratio of indoor/ambient sulfur in PM_2.5, a surrogate for residential ventilation

SUBMITTER: Maccarone J 

PROVIDER: S-EPMC10529440 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature