Clinical trait-specific genetic analysis in Behcet's disease identifies novel loci associated with ocular and neurological involvement.

ABSTRACT: Behçet's disease is a complex inflammatory vasculitis with a broad spectrum of clinical manifestations. The purpose of this study was to investigate the genetics underlying specific clinical features of Behçet's disease. A total of 436 patients with Behçet's disease from Turkey were studied. Genotyping was performed using the Infinium ImmunoArray-24 BeadChip. After imputation and quality control measures, logistic regressions adjusting for sex and the first five principal components were performed for each clinical trait using a case-case genetic analysis approach. A weighted genetic risk score was calculated for each clinical feature. Genetic association analyses of previously identified susceptibility loci in Behçet's disease revealed a genetic association between ocular lesions and HLA-

SUBMITTER: Casares-Marfil D 

PROVIDER: S-EPMC10529450 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature