Dopamine signaling from ganglion cells directs layer-specific angiogenesis in the retina.

ABSTRACT: During central nervous system (CNS) development, a precisely patterned vasculature emerges to support CNS function. How neurons control angiogenesis is not well understood. Here, we show that the neuromodulator dopamine restricts vascular development in the retina via temporally limited production by an unexpected neuron subset. Our genetic and pharmacological experiments demonstrate that elevating dopamine levels inhibits tip-cell sprouting and vessel growth, whereas reducing dopamine production by all retina neurons increases growth. Dopamine production by canonical dopaminergic amacrine interneurons is dispensable for these events. Instead, we found that temporally restricted dopamine production by retinal ganglion cells (RGCs) modulates vascular development. RGCs produce dopamine preci

SUBMITTER: Liang JH 

PROVIDER: S-EPMC10529464 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature