Biomimetic Approach to Diverse Coral Diterpenes from a Biosynthetic Scaffold.

ABSTRACT: Thousands of coral terpenes originate from simple scaffolds that undergo oxidative tailoring. While corals are excellent sources of drug leads, the challenge of supplying structurally complex drug leads from marine organisms has sometimes slowed their development. Making this even more challenging, in comparison to other organisms, such as plants and microbes, for which the terpene literature is substantial, very little is known about how the unique coral terpenes are biosynthesized and elaborated in nature. In this study, we used a semisynthetic strategy to produce at gram scale in yeast the eunicellane scaffold that underlies >200 coral compounds. Synthetic oxidation reactions were explored, generating key scaffolds that reflect three of the four structural classes derived from eunicella

SUBMITTER: Scesa PD 

PROVIDER: S-EPMC10529532 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature