Polygenic risk score in comparison with C-reactive protein for predicting incident coronary heart disease.

ABSTRACT:

Background and aims

Despite interest in the use of polygenic risk scores (PRS) for predicting coronary heart disease (CHD) risk, the clinical utility of PRS compared to conventional risk factors has not been demonstrated. We compared the performance of PRS with that of high-sensitivity C-reactive protein (hsCRP) in two well-established cohorts.

Methods

The study population included individuals of European ancestry free of baseline CHD from ARIC (N = 13,113) and the Framingham Offspring Study (FHS) (N = 2,696). The primary predictors included a validated PRS consisting of >6.6 million single nucleotide polymorphisms and hsCRP. The outcome was incident CHD, defined as non-fatal or fatal myocardial infarction. We compared the performance of both predictors after adjusting for t

SUBMITTER: Aday AW 

PROVIDER: S-EPMC10529589 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature