The EGF-motif-containing protein SPE-36 is a secreted sperm protein required for fertilization in C. elegans.

ABSTRACT: Identified through forward genetics, spe-9 was the first gene to be identified in C. elegans as necessary for fertilization.¹ Since then, genetic screens in C. elegans have led to the identification of nine additional sperm genes necessary for fertilization (including spe-51 reported by Mei et al.² and the spe-36 gene reported here).^{3,4,5,6,7,8,9} This includes spe-45, which encodes an immunoglobulin-containing protein similar to the mammalian protein IZUMO1, and spe-42 and spe-49, which are homologous to vertebrate DCST2 and DCST1, respectively.^4,7,8,10

SUBMITTER: Krauchunas AR 

PROVIDER: S-EPMC10529607 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature