Deploying solid-phase synthesis to access thymine-containing nucleoside analogs that inhibit DNA repair nuclease SNM1A.

ABSTRACT: Nucleoside analogs show useful bioactive properties. A versatile solid-phase synthesis that readily enables the diversification of thymine-containing nucleoside analogs is presented. The utility of the approach is demonstrated with the preparation of a library of compounds for analysis with SNM1A, a DNA damage repair enzyme that contributes to cytotoxicity. This exploration provided the most promising nucleoside-derived inhibitor of SNM1A to date with an IC₅₀ of 12.3 μM.

SUBMITTER: Arbour CA 

PROVIDER: S-EPMC10529636 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature