Design of Pectin-Based Hydrogel Microspheres for Targeted Pulmonary Delivery.

ABSTRACT: Pulmonary drug delivery via microspheres has gained growing interest as a noninvasive method for therapy. However, drug delivery through the lungs via inhalation faces great challenges due to the natural defense mechanisms of the respiratory tract, such as the removal or deactivation of drugs. This study aims to develop a natural polymer-based microsphere system with a diameter of around 3 μm for encapsulating pulmonary drugs and facilitating their delivery to the deep lungs. Pectin was chosen as the foundational material due to its biocompatibility and degradability in physiological environments. Electrospray was used to produce the pectin-based hydrogel microspheres, and Design-Expert software was used to optimize the production process for microsphere size and uniformity. The optimized

SUBMITTER: Chai A 

PROVIDER: S-EPMC10529711 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature