Understanding IP₃R channels: From structural underpinnings to ligand-dependent conformational landscape.

ABSTRACT: Inositol 1,4,5-trisphosphate receptors (IP₃Rs) are ubiquitously expressed large-conductance Ca²⁺-permeable channels predominantly localized to the endoplasmic reticulum (ER) membranes of virtually all eukaryotic cell types. IP₃Rs work as Ca²⁺ signaling hubs through which diverse extracellular stimuli and intracellular inputs are processed and then integrated to result in delivery of Ca²⁺ from the ER lumen to generate cytosolic Ca²⁺ signals with precise temporal and spatial properties. IP₃R-mediated Ca²⁺ signals control a vast repertoire of cellular functions ranging from gene transcription and secretion to the more enigmatic brain activities such as learning and memory. IP₃Rs open and release

SUBMITTER: Baker MR 

PROVIDER: S-EPMC10529787 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature