Obesity paradox or hypoxia preconditioning: How obstructive sleep apnea modifies the Obesity-MI relationship.

ABSTRACT:

Objectives

The objective of this study was to evaluate the interaction between obesity and obstructive sleep apnea on acute MI in hospital mortality.

Methods

This retrospective cohort study utilized Veterans Health Administration data from years 1999-2020. Participants were categorized according to their body mass index (BMI) to non-obese (BMI <30) and obese (BMI ≥30) groups. Clinical obstructive sleep apnea (SA) diagnosis was confirmed using ICD9/10 codes and the study subgroups included non-obese with no obstructive sleep apnea (nOB-nSA), non-Obese with obstructive sleep apnea (nOB-SA), obese with no obstructive sleep apnea (OB-nSA), and obese with obstructive sleep apnea (OB-SA). The primary outcome was odds ratio of in-hospital mortality during the hospitalization with a

SUBMITTER: Sharafkhaneh A 

PROVIDER: S-EPMC10529841 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature