Preoperative Predictors of Prolonged Opioid Use in the 6 Months After Total Knee Arthroplasty.

ABSTRACT:

Objectives

Prolonged postoperative opioid use increases the risk for new postsurgical opioid use disorder. We evaluated preoperative phenotypic factors predicting prolonged postoperative opioid use.

Methods

We performed a secondary analysis of a prospective observational cohort (n=108) undergoing total knee arthroplasty (TKA) for osteoarthritis with 6-week and 6-month follow-up. Current opioid use and psychosocial, pain, and opioid-related characteristics were assessed at preoperative baseline. Primary outcomes were days/week of opioid use at follow-up.

Results

At 6 weeks, preoperative opioid use and greater cumulative opioid exposure, depression, catastrophizing, anxiety, pain interference, sleep disturbance, and central sensitization were significantly associated wi

SUBMITTER: Larach DB 

PROVIDER: S-EPMC10529895 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature