In vivo variable and multi-day response from an insulin-releasing photoactivated depot.

ABSTRACT: Previously we have demonstrated that light can be used to control the release of insulin in diabetic animals, followed by a reduction in blood glucose. This is accomplished using a photoactivated depot (PAD) of insulin injected into the skin, and irradiated by a small external LED light source. In this work for the first time we demonstrate dose-response, showing that we can vary insulin release and commensurate blood glucose reduction by varying the amount of light administered. In addition to demonstrating dose-response, we have shown multi-day depot response, with insulin being released on two different days from the same depot. The material used in these studies was CD-insulin, a form of insulin that has a highly non-polar cyclododecyl group attached, markedly reducing the solubility o

SUBMITTER: Nadendla K 

PROVIDER: S-EPMC10529906 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature