Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review.

ABSTRACT: Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003 infected ∼8000 people in 26 countries with 800 deaths, which was soon contained and eradicated by syndromic surveillance and enhanced quarantine. A closely related coronavirus SARS-CoV-2, the causative agent of COVID-19 identified in 2019, has been dramatically more contagious and catastrophic. It has infected and caused various flu-like symptoms of billions of people in >200 countries, including >6 million people died of or with the virus. Despite the availability of several vaccines and antiviral drugs against SARS-CoV-2, finding new therapeutics is needed because of viral evolution and a possible emerging coronavirus in the future. The main protease (M^pro) of these coronaviruses plays impor

SUBMITTER: Li X 

PROVIDER: S-EPMC10529944 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature