Cerebellar morphological differences and associations with extrinsic factors in bipolar disorder type I.

ABSTRACT:

Background

The neural underpinnings of bipolar disorder (BD) remain poorly understood. The cerebellum is ideally positioned to modulate emotional regulation circuitry yet has been understudied in BD. Literature suggests differences in cerebellar activity and metabolism in BD, however findings on structural differences remain contradictory. Potential reasons include combining BD subtypes, small sample sizes, and potential moderators such as genetics, adverse childhood experiences (ACEs), and pharmacotherapy.

Methods

We collected 3 T MRI scans from participants with (N = 131) and without (N = 81) BD type I, as well as blood and questionnaires. We assessed differences in cerebellar volumes and explored potentially influential factors.

Results

The cerebellar cortex was sm

SUBMITTER: Harmata GIS 

PROVIDER: S-EPMC10529949 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature