Kidney-specific biomarkers for predicting acute kidney injury following cardiac arrest.

ABSTRACT:

Aim

To evaluate the performance of kidney-specific biomarkers (neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and cystatin-C) in early detection of acute kidney injury (AKI) following cardiac arrest (CA) when compared to serum creatinine.

Methods

Adult CA patients who had kidney-specific biomarkers of AKI collected within 12 h of return of spontaneous circulation (ROSC) were included. The association between renal biomarker levels post-ROSC and the development of KDIGO stage III AKI within 7 days of enrollment were assessed as well as their predictive value of future AKI development, neurological outcomes, and survival to discharge.

Results

Of 153 patients, 54 (35%) developed stage III AKI within 7 days, and 98 (64%) died prior to

SUBMITTER: Berlin N 

PROVIDER: S-EPMC10529996 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature