Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption.

ABSTRACT:

Background

Lymphatic vessels are responsible for tissue drainage, and their malfunction is associated with chronic diseases. Lymph uptake occurs via specialized open cell-cell junctions between capillary lymphatic endothelial cells (LECs), whereas closed junctions in collecting LECs prevent lymph leakage. LEC junctions are known to dynamically remodel in development and disease, but how lymphatic permeability is regulated remains poorly understood.

Methods

We used various genetically engineered mouse models in combination with cellular, biochemical, and molecular biology approaches to elucidate the signaling pathways regulating junction morphology and function in lymphatic capillaries.

Results

By studying the permeability of intestinal lacteal capillaries to lipoprote

SUBMITTER: Zarkada G 

PROVIDER: S-EPMC10530007 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature