Rare Variant Genetics and Dilated Cardiomyopathy Severity: The DCM Precision Medicine Study.

ABSTRACT:

Background

Dilated cardiomyopathy (DCM) can lead to advanced disease, defined herein as necessitating a durable left ventricular assist device or a heart transplant (LVAD/HT). DCM is known to have a genetic basis, but the association of rare variant genetics with advanced DCM has not been studied.

Methods

We analyzed clinical and genetic sequence data from patients enrolled between 2016 and 2021 in the US multisite DCM Precision Medicine Study, which was a geographically diverse, multiracial, multiethnic cohort. Clinical evaluation included standardized patient interview and medical record query forms. DCM severity was classified into 3 groups: patients with advanced disease with LVAD/HT; patients with an implantable cardioverter defibrillator (ICD) only; or patients with no

SUBMITTER: Hofmeyer M 

PROVIDER: S-EPMC10530109 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature