Association of delivery risk phenotype with early-onset sepsis in preterm infants.

ABSTRACT:

Objective

To determine delivery risk phenotype-specific incidence of early-onset sepsis (EOS) among preterm infants.

Study design

Retrospective cohort study of infants born <35 weeks' gestation at four perinatal centers during 2017-2021. Infants were classified into one of six delivery risk phenotypes incorporating delivery mode, presence of labor, and duration of rupture of membranes (ROM). The primary outcome was EOS incidence within the overall cohort and each risk phenotype.

Results

Among 2937 preterm infants, 21 had EOS (0.7%, or 7.1 cases/1000 preterm infants). The majority of EOS cases (13/21, 62%) occurred in the setting of prolonged ROM ≥ 18 h, with a phenotype incidence of 23.8 cases/1000 preterm infants. There were no EOS cases among infants born by cesarea

SUBMITTER: Coggins SA 

PROVIDER: S-EPMC10530160 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature