Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.

ABSTRACT: The previous study successfully established an expression strain of ζ-carotene-like compounds (CLC) and demonstrated its remarkable antioxidant activity, which exhibited resistance to photodamage caused by UVB radiation on the skin following gavage administration. The objective of this study was to investigate the impact and mechanism of CLC on UVB-induced skin damage through topical application. Cell viability, anti-apoptotic activity, ROS scavenging ability, the inhibition of melanin synthesis, the regulation of inflammatory factors and collagen deposition were assessed in cells and mice using qRT-PCR, WB, Elisa assays, immunohistochemistry staining and biochemical kits, etc. The experimental results demonstrated that CLC-mitigated apoptosis induced by UVB irradiation up-regulated the Ke

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10530282 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature