Differential Effects of the Betablockers Carvedilol, Metoprolol and Bisoprolol on Cardiac K_v4.3 (I_to) Channel Isoforms.

ABSTRACT: Cardiac K_v4.3 channels contribute to the transient outward K⁺ current, I_to, during early repolarization of the cardiac action potential. Two different isoforms of K_v4.3 are present in the human ventricle and exhibit differential remodeling in heart failure (HF). Cardioselective betablockers are a cornerstone of HF with reduced ejection fraction therapy as well as ventricular arrhythmia treatment. In this study we examined pharmacological effects of betablockers on both K_v4.3 isoforms to explore their potential for isoform-specific therapy. K_v4.3 isoforms were expressed in Xenopus laevis oocytes and incubated with the respective betablockers. Dose-dependency and biophysical characteristics were examined. HEK 293T-cells

SUBMITTER: Rahm AK 

PROVIDER: S-EPMC10530285 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature