Association of neighborhood deprivation with white matter connectome abnormalities in temporal lobe epilepsy.

ABSTRACT:

Objective

Social determinants of health, including the effects of neighborhood disadvantage, impact epilepsy prevalence, treatment, and outcomes. This study characterized the association between aberrant white matter connectivity in temporal lobe epilepsy (TLE) and disadvantage using a US census-based neighborhood disadvantage metric, the Area Deprivation Index (ADI), derived from measures of income, education, employment, and housing quality.

Methods

Participants including 74 TLE patients (47 male, mean age = 39.2 years) and 45 healthy controls (27 male, mean age = 31.9 years) from the Epilepsy Connectome Project were classified into ADI-defined low and high disadvantage groups. Graph theoretic metrics were applied to multishell connectome diffusion-weighted imaging (DWI) m

SUBMITTER: Chu DY 

PROVIDER: S-EPMC10530287 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature