Exploring the Transcriptome Dynamics of In Vivo Theileria annulata Infection in Crossbred Cattle.

ABSTRACT: The molecular changes occurring in the host in response to in vivo Theileria annulata parasitic infection are not well understood. Therefore, the present study investigated the differential expression profiles of peripheral blood mononuclear cells (PBMCs) across Theileria annulata-infected and non-infected crossbred cows. The differential expression profiles from PBMCs of infected and non-infected crossbred cows were generated by RNA sequencing. A marked difference in the expression of genes associated with innate immunity (FTH1, ACTB, ISG15) was observed between the two groups. The over-represented pathways in Theileria annulata-infected cows were associated with the immune system and regulation of the mitotic cycle. Enriched genes and pathways in

SUBMITTER: Ahlawat S 

PROVIDER: S-EPMC10530335 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature