Dataset Information

Establishment of a Seven-Gene Signature Associated with CD8⁺ T Cells through the Utilization of Both Single-Cell and Bulk RNA-Sequencing Techniques in Clear Cell Renal Cell Carcinoma.

ABSTRACT: Tumor immune microenvironment constituents, such as CD8⁺ T cells, have emerged as crucial focal points for cancer immunotherapy. Given the absence of reliable biomarkers for clear cell renal cell carcinoma (ccRCC), we aimed to ascertain a molecular signature that could potentially be linked to CD8⁺ T cells. The differentially expressed genes (DEGs) linked to CD8⁺ T cells were identified through an analysis of single-cell RNA sequencing (scRNA-seq) data obtained from the Gene Expression Omnibus (GEO) database. Subsequently, immune-associated genes were obtained from the InnateDB and ImmPort datasets and were cross-referenced with CD8⁺ T-cell-associated DEGs to generate a series of DEGs linked to immune response and CD8⁺ T cells. Patient

SUBMITTER: Chen Y

PROVIDER: S-EPMC10530336 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Dataset Information

Establishment of a Seven-Gene Signature Associated with CD8⁺ T Cells through the Utilization of Both Single-Cell and Bulk RNA-Sequencing Techniques in Clear Cell Renal Cell Carcinoma.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Establishment of a Seven-Gene Signature Associated with CD8+ T Cells through the Utilization of Both Single-Cell and Bulk RNA-Sequencing Techniques in Clear Cell Renal Cell Carcinoma.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Establishment of a Seven-Gene Signature Associated with CD8⁺ T Cells through the Utilization of Both Single-Cell and Bulk RNA-Sequencing Techniques in Clear Cell Renal Cell Carcinoma.