Spreading Depolarizations Suppress Hematoma Growth in Hyperacute Intracerebral Hemorrhage in Mice.

ABSTRACT:

Background

Spreading depolarizations (SDs) occur in all types of brain injury and may be associated with detrimental effects in ischemic stroke and subarachnoid hemorrhage. While rapid hematoma growth during intracerebral hemorrhage triggers SDs, their role in intracerebral hemorrhage is unknown.

Methods

We used intrinsic optical signal and laser speckle imaging, combined with electrocorticography, to investigate the effects of SD on hematoma growth during the hyperacute phase (0-4 hours) after intracortical collagenase injection in mice. Hematoma expansion, SDs, and cerebral blood flow were simultaneously monitored under normotensive and hypertensive conditions.

Results

Spontaneous SDs erupted from the vicinity of the hematoma during rapid hematoma growth. We found t

SUBMITTER: Fischer P 

PROVIDER: S-EPMC10530404 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature