Predictive Value of Early Inflammatory Markers in Trauma Patients Based on Transfusion Status.

ABSTRACT:

Introduction

Seven key inflammatory biomarkers were recently found to be associated with the risk of mortality in a multicenter study of massively transfused patients. The aim of this prospective single-center study was to determine which of these early inflammatory markers could predict 30-d mortality among all critically injured trauma patients.

Methods

Serum samples were collected at 6, 24, and 72 h from 238 consecutive patients admitted to the intensive care unit following traumatic injury. Inflammatory markers syndecan-1, eotaxin, IL-1ra, IL-6, IL-8, IL-10, IP-10, and MCP-1 were analyzed via multiplex enzyme-linked immunosorbent assay. Subgroup analysis was performed for patients undergoing massive transfusion (≥5 red blood cells), submassive transfusion (1-4 red blood

SUBMITTER: Baucom MR 

PROVIDER: S-EPMC10530444 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature